NMN

1) Product Name: β-nicotinamide mononucleotide

Synonyms: Nicotinamide mononucleotide; Nicotinamide ribonucleoside 5′-phosphate; Nicotinamide ribonucleotide; Nicotinamide ribotide; beta-D-NMN; beta-NMN
Molecular formula: C11H15N2O8P
Molecular weight: 334.22
CAS Registry Number: 1094-61-7
EINECS accession number: 214-136-5

2) What’s β-nicotinamide mononucleotide ?

2.1) NMN (Nicotinamide mononucleotide): The full name is “β-nicotinamide mononucleotide”, which is a naturally occurring biologically active nucleotide.

There are two irregular forms of NMN, α and β; β isomer is the active form of NMN with a molecular weight of 334.221 g/mol. Because nicotinamide belongs to vitamin B3, NMN belongs to the category of vitamin B derivatives.

2.2)Many biochemical reactions in the human body widely involve it, and it is closely related to immunity and metabolism..

At the molecular level, it is ribonucleic acid, the basic structural unit of nucleic acid RNA. Structurally, the molecule consists of nicotinamide, ribose and phosphate groups. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered to be a key component to increase the level of NAD+ in cells. The substances inherent in the human body are also rich in some fruits and vegetables.

3） What is the health benefit for NMN to human body? 

3.1) In the human body, NMN is the most direct precursor of NAD+, and its function is manifested through NAD+.

NAD+ is also called Coenzyme I, and its full name is nicotinamide adenine dinucleotide. It exists in every cell and participates in thousands of reactions. In a variety of cellular metabolic reactions, nicotinamide adenine dinucleotide (NAD) molecules play an important role and are an important support for cells to maintain vitality.

3.1) The decline of NAD in the aging process is considered to be the main cause of diseases and disability, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiency, arthritis, metabolic disorders and cardiovascular diseases caused by dysregulation of autoimmune inflammation.

Therefore, supplementation of NMN increases the NAD+ content in the body, thereby delaying, improving, and preventing various phenotypes related to aging, or age-induced metabolic disorders, senile diseases, etc.

4) How does NMN work? 

4.1) It is a nutrient substance that cells can convert into NAD+.

It is classified as a brand-new vitamin B3, and it surpasses the efficacy of ordinary vitamins. It is considered as a supplement to prevent aging and restore youth.

4.2) It is a substance contained in the human body, present in breast milk and food, such as edamame, broccoli, cucumber, cabbage, avocado, tomato, etc., but the content is very small (0.25-1.88 mg per 100 g).

Raw beef and shrimp also contain very small amounts (0.06-0.42 mg per 100 grams) of NMN. Therefore, if you want to improve NMN, you must directly supplement it from the outside world.

4.3) With age, the decrease of NAD+ level leads to the decline of DNA repair ability, accumulation of DNA damage, and drive the aging process. NAD+ participates in cellular respiration in cells and promotes energy metabolism (such as oxidation of glucose, fat, and amino acids).

NAD+ is not only a coenzyme for hundreds of redox reactions in living cells, it also acts as a substrate to regulate cell survival, cell apoptosis, DNA repair, immune response, circadian rhythm and other physiological functions.

5) What is the difference between NMN and NR? 

Nicotinamide Adenine Dinucleotide (NAD+) Comparison
NAD+ is an essential coenzyme found in all living cells that aids in cellular processes and energy production. Unfortunately, as the human body ages, NAD+ levels naturally decline, which researchers believe may contribute to aging and associated diseases. Scientists are investigating methods to raise NAD+ concentrations to compensate for this loss. This has led to interest in nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), which can convert to NAD+ through biochemical pathways. Both NR and NMN represent precursor molecules with the ability to boost NAD+ levels. However, before utilizing any NR or NMN supplements, it is important to understand the distinguishing characteristics of each compound.

6) Is NMN the Most Exciting Anti-Aging Discovery Yet?

 6.1) Powerful Anti-aging 

NMN has gotten a ton of attention in the search for powerful anti-aging treatments thanks to its role in making NAD+, a super important molecule our cells need for energy production and DNA repair. While NMN shows a lot of promise in fighting age-related decline, we can’t say for sure it’s the “best” without looking more closely at its possible benefits and current limitations.

Finding the most effective anti-aging supplement doesn’t need to be a drag. Studies in animals are very promising – they suggest NMN supplements may slow down aging by boosting cell functions, metabolism, and overall health. This gets people pumped about NMN working for humans too.

6.2) Still Need more proof 

But we still need more proof NMN has long-lasting anti-aging effects in people. Clinical trials are testing NMN’s safety, how well it works, and specific impacts on aging issues. It’s key to know aging involves many complex processes influenced by our DNA, lifestyle, and environment – and that may limit how well any one anti-aging method works alone.

Also, while NMN refills NAD+ levels, other aging factors like oxidative stress, inflammation, and cell aging still need addressing. Dealing with all aspects of aging may take a more complete approach beyond just NMN supplements.

6.3) Conclusion:  Need more comprehensive anti-aging strategy.

For now, it’s too soon to say for sure it is the definite “best” anti-aging solution. It’s a fascinating area of anti-aging research with potential to support cell health and vitality. But more exploration and a deeper understanding within the full context of aging as a multifaceted process are needed to know its safety, effectiveness, and long-term impacts. Combining NMN with a holistic lifestyle and other targeted approaches may lead to a more comprehensive anti-aging strategy.

7) Where to buy β-nicotinamide mononucleotide? 

Shanghai ZNCBIO is a supplier for many anti-ageing supplement ingredients, such as CO enzyme Q10, Nicotinamide Riboside etc.  Products cover many fields: such as Nutritional supplements, Food additives, APIs, Dietary supplement, Cosmetics and minerals. You could get professional and customized service for any inquiry within 12 hours from ZNCBIO.