Keylights:
- Nicotinamide Riboside serves as a vitamin B3 precursor for NAD+. This coenzyme plays an important role in numerous body processes.
- Supplements containing NR are often used to boost energy, improve DNA repair, enhance cognitive health, and reduce heart disease.
- The most commondose is 250-500 mg per day.
- When used correctly, NR has been shown to be well tolerated and safe.
You may be interested in healthy aging. You may be looking for supplements to optimize your workout efficiency. You’ve probably heard of NR, a hot topic in the world of anti-aging.
What is Nicotinamide Riboside?
Vitamin B3 encompasses several compounds, including niacin (nicotinic acid), nicotinamide (niacinamide), and nicotinamide riboside.. It’s found in fruits, vegetables, meat, and milk.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People utilize nicotinamide riboside for various purposes such as anti-aging supplements, managing high cholesterol, high blood pressure, Alzheimer’s disease, and obesity among others. However, it’s important to note that there is currently no substantial scientific evidence to conclusively support these applications. It’s also crucial not to conflate nicotinamide riboside with niacin, niacinamide, or NADH, as these are related but distinct substances.
Is Niacinamide (Vitamin B3) and nicotinamide Riboside the same?
Vitamin B3, Niacin is also known as niacinamide and nicotinamide-riboside.
This important micronutrient may be as common as your daily multivitamin but it’s not as mundane as you might think. The safety and molecular aspects of vitamin B3 are not always obvious.
Vitamin B3 (niacin) is almost always labeled as the same thing in multivitamins.
Nicotinamide NAM, also known as niacinamide has a molecularly different structure but acts in a similar way to niacin. This slight difference allows nicotinamide bypass the irritating flushing caused by niacin, and provide the benefits of vitamin b3 without making you feel self-conscious.
What is the difference between NR & NMN?
The biosynthesis of nicotinamide adenine dinucleotide, or NAD+, begins with nicotinamide mononucleotide and nicotinamide riboside. NAD+ concentrations decrease during aging. Many studies have shown that restoring NAD+ in older animals can extend their lifespan and promote health. The two molecules have been studied and it has been shown that supplementing with either of them increases NAD+ during aging. What is the difference between these NAD+ molecules?
The differences between NMN (NMN) and NR are their molecular structure, as well as how the cells biosynthesize them to NAD+.
NMN’s molecular structure is similar to that of NR, but NMN contains an additional phosphate group. This extra phosphate group is what makes NMN a bigger molecule than NR. Scientists believe NMN cannot cross cellular membranes, and it must be converted to NR in order to enter cells where NAD+ is synthesized. NMN must be transported into the cells via a transporter that is specific to NMN.
What are the Nicotinamide Riboside Benefits?
Any Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian or registered dietitian nutritionist (RD or RDN), pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease.
Nicotinamide riboside supplementation is in the early stages of study, with limited amounts of data using human subjects.
It is also unclear as to how much of the increased levels of NAD+ that NR produces are actually used by the body vs. simply being excreted in the urine.
1. Support for cell energy production
NAD+ is the primary cellular target of NR. The sirtuin protein is also a major target. NAD+, or nicotinamide-adenine dinucleotide, is an important coenzyme for converting food to cellular fuel. The food must be broken down into its smallest components, sugars, amino acids, and fats. Our mitochondria produce cellular energy to fuel biochemical reactions within our cells.
As we age, other environmental and cell insults negatively affect our bodies, this process naturally slows down. This situation can be mitigated by substances that stimulate the activity of sirtuins. These proteins are responsible for making our cells more metabolically efficient. The sirtuins only work in the presence NAD+.
2. Support for brain function
Increased NAD+ in nerves and brain cells stimulates the enzymes responsible for cognitive function and neuroplasticity, the ability of brain cells to adapt and learn from their environment. It also increases the activity of the PCG-1-alpha enzyme, which encourages our cells’ mitochondria to grow.
3. Supporting healthy metabolism
Our cells become more metabolically active when NAD+ or sirtuins levels are increased. They are also more efficient in converting food into fuel. This allows us to use insulin and cholesterol more efficiently, as well as maintain a normal inflammation response.
4. Support for normal liver function
Liver cells are among the most metabolically active cells in the human body. Liver cells are constantly detoxifying unwanted substances, both from the inside (endotoxins), and outside (exotoxins from food or the environment). Supporting NAD+ and mitochondrial function helps the liver cells and reduces the likelihood of fat accumulating in the liver. We also encourage a normal inflammation response.
5. Support Exercise efficiency
NAD+ plays a vital role in the Krebs cycle, as well as the electron transport chain. NAD+ is essential for mitochondrial energy production in heart and muscle tissue. It also boosts ATP production, which can be beneficial to endurance athletes.
6. Supporting healthy aging
In animal studies, it was shown that supporting NAD+ and sirtuin protein production can slow down the aging process. While there is no “anti-aging” product, supporting the sirtuins and NAD+ in the mitochondria can support healthy aging.
Contrary to the wild claims of some salespeople, there is no such thing as a miracle supplement. NR promotes optimal metabolic function, mitochondrial activity , and a normal inflammation response. Enhancing cellular function helps us age better, stay sharper, maintain a normal metabolism, detoxify and cleanse our bodies.
Nicotinamide Riboside: How to take it
Nicotinamide Riboside comes in tablet, liquid, powdered and capsule form.
Nicotinamide Riboside is available as a supplement alone or combined with other nutrients such as Vitamin B, minerals, and herbal ingredients.
Nicotinamide Riboside can be taken in multiple doses throughout the day.
Risks and side effects
Nicotinamide Riboside is safe to use and tolerated when used correctly.
A study published in Scientific Reports evaluated the safety and metabolism for NR supplements.
Researchers found that when NR at doses of 100, 300, and 1,000 milligrams was administered during an 8-week, randomized double-blind placebo-controlled trial, the NAD+ level increased and there were no adverse effects.
Other human studies found that taking up to 2,000 mg per day was well tolerated and had no adverse effects. Be sure to consult your doctor before increasing the dose of NR.
As previously mentioned, nicotinamide supplements are likely to be safe if you follow the dosage recommended on the label. Consult your doctor before exceeding the recommended daily serving of 250-500 mg.
The new generation vitamin B3 is nicotinamide-riboside.
Nicotinamide-riboside, the cutting-edge vitamin B3 of the future, is making waves in the health and wellness community. This innovative form of vitamin B3 is heralded for its potential in boosting NAD+ levels, a coenzyme vital for cellular function. Research indicates that nicotinamide-riboside supplementation may offer a wide array of benefits, from supporting metabolic processes to promoting brain health and possibly extending lifespan. As scientists delve deeper into its mechanisms and applications, the future looks bright for this promising nutrient.
Storage and stability of NMN
According to a stability analysis, NR remains stable (doesn’t degrade) at room temperature for six hours and at temperatures between two and eight degrees Celsius for seven days. David Sinclair PhD, A.O., discusses the stability of NMN and NR . Harvard University advises that NR and Nmn should be kept cold. If the NR and NMN is not stabilized, it will degrade into nicotinamide. This is something that you do not want to consume in high doses because my lab has shown many years ago how nicotinamide inhibits the sirtuins and PARP, as well as interfering with DNA repair.
Where do I find quality Nicotinamide Riboside Chloride Powder?
ZNCBIO is the best place to order in bulk if you need a raw material like Nicotinamide Riboside. We offer a variety of products with low minimum order Qty, at competitive prices. We also provide certificates of analysis, MSDS and third-part test reports. Sample is also available per your request.
Visit our website at www.zncbio.com for more information on ZNCBIO.
Conclusion:
Nicotinamide riboside (NR) is a promising supplement that offers numerous health benefits by increasing NAD+ levels in the body. As a more efficient precursor to NAD+ compared to other forms of vitamin B3, NR is effective in supporting cellular energy production, enhancing mitochondrial function, and promoting overall metabolic health. While generally safe for most people, it is important to be aware of potential side effects and consult with a healthcare provider before starting supplementation, especially for individuals with pre-existing health conditions. Daily supplementation of NR, particularly in doses around 500 mg, has been shown to be safe and beneficial. As research continues, the understanding of NR’s potential and long-term safety will further inform its use in promoting health and longevity.