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TAURINE
Tirzepatide
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of type 2 diabetes and weight management. It is an important sports nutrition ingredient. ZNCBIO is a professional Tirzepatide China supplier and manufacturer, we have rich experience for exporting. Please be sure to email us at info@zncbio.com when you have any demands.
CAS No.: 2023788-19-2
TYPE: JP GRADE & USP GRADE
BRAND: ZNCBIO
MOQ: 1.0 G
Introduction of Tirzepatide
Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R. Tirzepatide is a synthetic peptide with glucose-lowering effects.
It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner. Tirzepatide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
Tirzepatide comprises a 39 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety through a hydrophilic linker at the lysine residue at position 20. Due to this moiety, the compound is highly bound to albumin in the plasma which prolongs its half-life. It contains two non-coded amino acid residues (Aib, alpha-amino isobutyric acid) at positions 2 and 13).
Basic Information
- Molecular Formula: C225H348N48O68
- Molecular Weight: 4813.03 g/mol
- Appearance: White or off-white lyophilized powder
- Purity: ≥98% (HPLC tested)
- Packing specifications: 1g、10g、50g、100g、1kg, etc. (can be customized according to customer needs)
- Solubility: Soluble in water or buffer solution
Physical and Chemical Properties
- Storage Conditions: Store at low temperature (-20°C or below), protected from light, and sealed.
- Stability: Avoid repeated freeze-thaw cycles; recommended to prepare fresh solutions before use.
- Biological Activity: Dual agonist of GLP-1 and GIP receptors.
- Analytical Methods: HPLC, MS, NMR.
Function of Tirzepatide
Tirzepatide functions primarily as a dual agonist of two important hormones involved in glucose metabolism and appetite regulation: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These functions include:
1. Blood Sugar Regulation:
- Enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose is elevated, helping to lower blood sugar levels.
- Reduces glucagon secretion, which helps prevent the liver from producing too much glucose.
2. Weight Loss:
- Suppresses appetite by acting on areas of the brain that control hunger.
- Slows gastric emptying, leading to a feeling of fullness for a longer period, thus reducing overall calorie intake.
3. Improved Insulin Sensitivity:
- Increases insulin sensitivity in tissues, which aids in better glucose uptake and usage.
Key Effects:
- Lower blood glucose levels in patients with type 2 diabetes.
- Promotes weight loss in individuals with type 2 diabetes or those with obesity.
- Improves overall metabolic control, benefiting those with insulin resistance.
Tirzepatide has shown significant efficacy in clinical trials, especially in reducing HbA1c and body weight.
Application of Tirzepatide
Tirzepatide is primarily used for the treatment of type 2 diabetes and weight management, and it is typically used in the following types of products:
1. Diabetes Treatment Medications
Injectable: Tirzepatide, as an injectable medication, is commonly administered in the form of a pre-filled injection pen, allowing patients to self-administer subcutaneous injections at home. It helps to control blood sugar, particularly for those with type 2 diabetes, effectively lowering blood sugar levels (HbA1c).
2. Weight Loss Medications
Tirzepatide has been shown to promote weight loss, and it is thus used in weight management products, especially for patients with obesity or those who are overweight. It helps with weight loss by suppressing appetite and reducing calorie intake.
3. Combination Therapy
In some cases, Tirzepatide may be used as part of a combination therapy alongside other medications (such as insulin or other oral hypoglycemic agents) to enhance treatment outcomes.
Product Types:
Single Drug Injection: For example, Mounjaro (the brand name for Tirzepatide), a once-weekly injection medication used for type 2 diabetes and weight management.
Weight Loss Medications: It may also be studied and used as a specific treatment for obesity.
Tirzepatide is mainly used in medical products related to diabetes and weight management. Please contact us if you would like to learn more.
Contact Details
SHANGHAI ZNCBIO
Precautions for Using Tirzepatide
When using Tirzepatide raw powder in a pharmaceutical manufacturing facility, the following points must be considered:
Raw Material Verification: Ensure the powder comes from a compliant supplier and meets quality standards (e.g., HPLC, MS testing).
Storage Conditions: The powder should be stored at below -20°C, protected from light, and avoid repeated freeze-thaw cycles.
Production Environment: Manufacturing should take place in a GMP-compliant clean environment with strict control of temperature and humidity.
Operational Standards: Operators must receive GMP training and use appropriate protective equipment.
Quality Control: Rigorous quality control and stability testing should be conducted during production to ensure the safety and efficacy of the drug.
Waste Management: Waste should be handled according to regulations to prevent contamination.
Following these precautions ensures the quality of Tirzepatide and the safety of patients.For more information, please contact us.
More Product Recommendations
Shanghai ZNC Biotechnology Co., Ltd.(ZNCBIO) is a supplier of various chemicals and packaging materials. In addition to Tirzepatide , it can also provide you with products in many fields such as nutritional supplements, food additives, APIs, cosmetics and minerals.
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